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KMID : 0358419950380101871
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Korean Journal of Obstetrics and Gynecology
1995 Volume.38 No. 10 p.1871 ~ p.1880
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A Study of Relationship between Drug, Environment and Congenital Anomaly
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Abstract
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A study was undertaken by questionaire to 7025 mothers who delivered at CHA general hospital from Nov. 1992 to Dec. 1993, considering their exposure to drug, environment or other potential teratogenic substances. Those who delivered their babies
without
amy malformations. Were classified as the control group, and those with the malfomations as the study group.
@ES The results were as follows.
@EN 1. 6707 cases delivered their babies without any malfomations and 319 cases(4.5%) with malfomations.
2. There were no significant age difference in both groups, but the incidence of delivering malformed children were higher in mothers above 34 years.
3. About 1/3 of the of paturients were working mothers. There were no significant differences according to occupational bases, but there was a tendency of more teachers in the control group.
4. About 50% of mothers in both group were exposed to drugs or other potentially hazadous substances. Those of about 30% were exposed to radiation or drug. About 1/4 of mothers in both group who were exposed to radiation, drug, noxious gas,
alchohol or
tobacco in first trimester were not aware of their pregnancy.
5. 72% of total mother drank coffee, 4.9% alchohol, 1.2% tobacco and there is no significant difference between two groups. 39.4% of control group and 39.2% of study group drank coffee in the first trimester, 3.2 and 2.2% alchohol, 0.8 and 0.9%
tobacco
respectively but there was no significant difference.
6. α-feto protein value was measured to be 1.80±0.38(Mean±S.D.) MOM(Multiple of the median for the population) for the control group and 1.21±0.50(Mean±S.D) MOM for the study group which was not significantly different. The study group had
more
motheres with α-feto protein value below 0.5 MOM, 2.0~2.4MOM and over 2.4 MOM than control group.
7. The organs involved in congenital malformation were skin including ear in 66 cases(0.9%), cardiovascular system 59 cases(0.8%), urogenital system was cases(0.7%), skeletal system 46 cases(0.7%) and digestive system was 24 cases(7.5%).
Considering
the congenital malformation involving these organs and complex abnomalities, there was no significant difference between both groups, whether they were working mothers, drug users, drinkers or tobacco smokers.
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KEYWORD
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